After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!
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Brendan Fraser
Stu Miley
Bridget Fonda
Dr. Julie McElroy
John Turturro
Monkeybone (voice)
Chris Kattan
Organ Donor Stu
Giancarlo Esposito
Hypnos
Rose McGowan
Miss Kitty
Dave Foley
Herb
Megan Mullally
Kimmy Miley
Bob Odenkirk
Head Surgeon
Whoopi Goldberg
Death
Pat Kilbane
Burger God Representative
Lisa Zane
Medusa
Sandra Thigpen
Alice
Wayne Wilderson
Hutch
Amy Higgins
Clarissa
“Get boned!”
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